Direct Coupling Analysis (DCA)

Direct Coupling Analysis (DCA) is a statistical inference framework used to infer direct co-evolutionary couplings among residue pairs in  multiple sequence alignments. A recent formulation of DCA termed mean field DCA (mfDCA), provides the computational power to apply this tool in a high throughput manner to a number of protein and domain families. mfDCA was able to uncover a large number of native intra-domain and inter-domain residue-residue contacts in many domain families.