Proteins regulate biological processes through a complex network of dynamical interactions. In our team, we address two crucial issues linked to protein interactions:
- What are the regions at a protein surface that interact with partners?
- Who interact with whom in the cell?
I have developed JET2
, a method exploiting both sequence and structure information to unravel the complxity of protein interfaces associated to different partners and of different origins. JET2 was applied to the whole Protein Bata Bank (predictions available here: JET2Viewer
). The method is now being extended to the prediction of protein-DNA binding sites. I showed that the knowledge of a protein's global social behaviour, inferrred from complete cross-docking calculations
, informs us on its specific cellular partners. I participated in the development of LISA
, a function that estimates protein-protein binding affinities based on density functional theory.