Laboratory of Computational and Quantitative Biology (LCQB)
UMR 7238 CNRS - Sorbonne Université
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Targeting Solute Carrier Transporters through Functional Mapping.
| Title | Targeting Solute Carrier Transporters through Functional Mapping. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Colas, C, Laine, E |
| Journal | Trends Pharmacol Sci |
| Volume | 42 |
| Issue | 1 |
| Pagination | 3-6 |
| Date Published | 2021 01 |
| ISSN | 1873-3735 |
| Keywords | Humans, Ligands, Membrane Transport Proteins, Solute Carrier Proteins |
| Abstract | Solute carrier (SLC) transporters are emerging drug targets. Identifying the molecular determinants responsible for their specific and selective transport activities and describing key interactions with their ligands are crucial steps towards the design of potential new drugs. A general functional mapping across more than 400 human SLC transporters would pave the way to the rational and systematic design of molecules modulating cellular transport. |
| DOI | 10.1016/j.tips.2020.11.005 |
| Alternate Journal | Trends Pharmacol Sci |
| PubMed ID | 33234336 |
