The Laboratory of Computational and Quantitative Biology (LCQB), headed by A. Carbone, is an interdisciplinary laboratory working at the interface between biology and quantitative sciences. It is built to promote a balanced interaction of theoretical and experimental approaches in biology and to foster the definition of new experimental questions, data analysis and modeling of biological phenomena. Our projects address questions on biological structures and processes through the gathering of experimental measures, the in silico generation of new biological data that remain inaccessible to experiments today (modeling of biological systems), the development of statistical methods for data analysis, and the conception of original algorithms aimed to predictions. The lab is supported by the CNRS and Sorbonne Université.


June 10, 2019

What can proteins tell us about how they interact and function together? At LCQB, we develop computational approaches to predict protein interactions, model protein social behaviour and infer the effect of mutations on protein interaction networks. We just posted this video explaining these ideas to the large public. 

Link to the french video

Link to the italian video

November 25, 2021

Le stockage des données sur ADN : une technologie révolutionnaire développée par Stéphane Lemaire et Pierre Crozet, spécialistes de biologie synthétique au laboratoire de biologie computationnelle et quantitative et cofondateurs de la startup Biomemory.


Pour aller plus loin:
La révolution de l'ADN (reportage au journal de France 3 Ile de France)
Le stockage des données sur l'ADN : une technologie révolutionnaire
Des archives numériques encodées sur ADN entrent aux Archives nationales

November 18, 2021

A full professor position is open at the Laboratory for Computational and Quantitative Biology (LCQB), Institut de Biologie Paris Seine (IBPS), Sorbonne University (SU) with a starting date from September 2022.

Find here the description.

November 9, 2021

A 2-year postdoctoral position is available in the “Biology of Genome" team. The selected candidate will work on a project aimed at understanding the mechanisms leading to high levels of heterozygosity and polyploidy in Saccharomyces cerevisiae, using both experimental works and bioinformatics analyses of genome sequences. Find here the detailed description of the position

October 18, 2021

Postdoctoral position available in the "Analytical Genomics" team. Find here the description.

A 2-year postdoctoral fellowship is open to develop new computational methods leading to the reconstruction of the protein mutational phenotypic landscapes and the evaluation of protein mutations in multimeric proteins.

Computational approaches developed in this "proof of concept" project should be transferable to all the genes involved in genetic diseases for which functional assays exist or can be designed.

September 20, 2021

A postdoctoral position in telomere, DNA damage response and genome instability is available in the "Telomere and Genome Stability" team. Find here the description."

August 21, 2021

The analysis of the subtelomeres of a green alga, published in Nucleic Acids Research, is featured in this press release on the INSB website. The work, a collaboration between the LCQB ("Telomere and Genome Stability" and "Biology of Genomes" teams) and the IBPC, sheds light into the complexity and evolution of the subtelomeres, structures that are critical for genome integrity.

July 26, 2021

A press release from the ANRS on our eLife article


July 19, 2021

We provided crucial insights to the molecular mechanism through which HBV infects cells. A fusion peptide in preS1 and the human protein-disulfide isomerase ERp57 are involved in HBV membrane fusion process.

Link to the article

July 14, 2021

The startup BIOMEMORY, cofounded by Stéphane Lemaire and Pierre Crozet with Erfane Arwani is the winner of the 23rd i-Lab 2021 innovation competition. The "i-Lab" objective is to detect projects for the creation of innovative technology companies and to support the best of them with financial aid and appropriate follow-up. Congratulations to Stephane, Pierre and Erfane! See the article here.