The Laboratory of Computational and Quantitative Biology (LCQB), headed by A. Carbone, is an interdisciplinary laboratory working at the interface between biology and quantitative sciences. It is built to promote a balanced interaction of theoretical and experimental approaches in biology and to foster the definition of new experimental questions, data analysis and modeling of biological phenomena. Our projects address questions on biological structures and processes through the gathering of experimental measures, the in silico generation of new biological data that remain inaccessible to experiments today (modeling of biological systems), the development of statistical methods for data analysis, and the conception of original algorithms aimed to predictions. The lab is supported by the CNRS and the University Pierre and Marie Curie (UPMC).

Upcoming Events

June 13-25, 2016

Marco Cosentino Lagomarsino co-organizes the second edition of the workshop: "Quantitative Laws II. From physiology to ecology, from interaction structures to collective behavior".

June 27-July 1, 2016

Alessandra Carbone organises with Ion Petre (Turku Centre for Computer Science) the special session "Computation in biological systems" at the international conference "Computability in Europe 2016", Université Paris 7, June 27th 2016 - July 1st 2016. Speakers are Daniela Besozzi (University of Milan-Biccocca), Eugen Czeizler (Åbo Akademi University), Vincent Moulton (University of East Anglia), Eric Tannier (INRIA and University of Lyon).

July 11-16, 2016

Martin Weigt co-organizes the conference "Statistical physics methods in biology and computer science", a satellite of StatPhys2016, Ecole Normale Superieure, Paris, July 11-16, 2016. It will cover recent progress on the use of methods from statistical mechanics of disordered systems for high dimensional problems related to biology and computer science. Organizers: Simona Cocco, Florent Krzakala, Remi Monasson, Guilhem Semerjian, Martin Weigt, Lenka Zdeborova. 

News

May 2, 2016

The team of Diatom Functional Genomics just published a paper describing how marine diatoms efficiently attune acclimation responses in highly variable ocean environments. L.Taddei*, G.R. Stella*, A. Rogato, B. Bailleul, A.E. Fortunato, R. Annunziata, R. Sanges, M. Thaler, B. Lepetit, J. Lavaud, M. Jaubert, G. Finazzi, J.P. Bouly, A. Falciatore. Multi-signal control of expression of the LHCX protein family in marine diatom Phaeodactylum tricornutum.  Journal Experimental Botany, in press.

*co-first-authors

April 17-23, 2016

Martin Weigt organizes the workshop "Coevolution in proteins and RNA, theory and experiments" in Cargèse, Corsica

April 13, 2016

We achieved the complete reconstruction of genome history in a model yeast genus, providing a granular view of genome evolution linking gene content, chromosome rearrangements and protein divergence into a single evolutionary framework.

N Vakirlis, Sarilar V, G Drillon, A Fleiss, N Agier, J-P Meyniel, L Blanpain, A Carbone, H Devillers, K Dubois, A Gillet-Markowska, S Graziani, Nguyen H-V, M Poirel, C Reisser, J Schott, J Schacherer, I Lafontaine, B Llorente, C Neuvéglise and Fischer G. Reconstruction of ancestral chromosome architecture and gene repertoire reveals principles of genome evolution in a model yeast genus. Genome Research (2016) in press.

March 1, 2016

A.E. Fortunato, M. Jaubert, J.P. Bouly, M. Thaler and A. Falciatore from the Diatom Functional Genomics team in collaboration with J.S. Bernardes (Statistical Genomics and Biological Physics), A. Carbone (Analytical Genomics) and other international collaborators published on The Plant Cell the paperDiatom Phytochromes Reveal the Existence of Far-Red-Light-Based Sensing in the Ocean.”  Full text paper.

Plant Cell Editor’s comment on this work.

January 1, 2016

E.Laine and A.Carbone just published a new large-scale method to predict protein-protein interfaces based on sequence and structure information - Joint Evolutionary Trees 2 (JET2). It is the first time that a method highlights, with such a precision, information on distinguished binding sites, possibly overlapping each other.

To the Article and Software.

December 21, 2015

Interview of the German National Radio to A.Carbone, where she gives some highlights on protein-protein interactions.
 

December 7-8, 2015

Marco Cosentino Lagomarsino co-organizes the 3rd edition of Quantitative Methods in Gene Regulation,
Corpus Christi College, Cambridge, UK. 

November 5-6, 2015

The 5th Cross Disciplinary Genomics meeting "Genomics of Microbial Communities" will be held at UPMC.
There is no participation fee but registration is required.

October 26, 2015

M.Punta, S.Longhi (University of Marseille) and A.Carbone organise the workshop "A DAY IN THE LIFE OF INTRINSICALLY DISORDERED PROTEINS: FROM COMPUTATION TO EXPERIMENTS" at the Ecole Nationale Supérieure de Chimie de Paris, Amphithéâtre Moissan.

No fee is required but registration is mandatory.

July 12-16, 2015

The symposium The evolution of alternative splicing  is co-organized within the framework of the 2015 meeting of the Society for Molecular Biology and Evolution by E. Laine (LCQB), H. Richard (LCQB), and J. Roux (UNIL). The event will take place in Vienna, Austria.
Registration is now open.  Abstract submission for oral presentation closes on February 8th.

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