The Laboratory of Computational and Quantitative Biology (LCQB), headed by A. Carbone, is an interdisciplinary laboratory working at the interface between biology and quantitative sciences. It is built to promote a balanced interaction of theoretical and experimental approaches in biology and to foster the definition of new experimental questions, data analysis and modeling of biological phenomena. Our projects address questions on biological structures and processes through the gathering of experimental measures, the in silico generation of new biological data that remain inaccessible to experiments today (modeling of biological systems), the development of statistical methods for data analysis, and the conception of original algorithms aimed to predictions. The lab is supported by the CNRS and Sorbonne Université.

News

June 10, 2019

What can proteins tell us about how they interact and function together? At LCQB, we develop computational approaches to predict protein interactions, model protein social behaviour and infer the effect of mutations on protein interaction networks. We just posted this video explaining these ideas to the large public. 

Link to the french video

Link to the italian video

Video
Analytical Genomics
October 18, 2021

Postdoctoral position available in the "Analytical Genomics" team. Find here the description.

A 2-year postdoctoral fellowship is open to develop new computational methods leading to the reconstruction of the protein mutational phenotypic landscapes and the evaluation of protein mutations in multimeric proteins.

Computational approaches developed in this "proof of concept" project should be transferable to all the genes involved in genetic diseases for which functional assays exist or can be designed.

Job
September 20, 2021

A postdoctoral position in telomere, DNA damage response and genome instability is available in the "Telomere and Genome Stability" team. Find here the description."

Job
August 21, 2021

The analysis of the subtelomeres of a green alga, published in Nucleic Acids Research, is featured in this press release on the INSB website. The work, a collaboration between the LCQB ("Telomere and Genome Stability" and "Biology of Genomes" teams) and the IBPC, sheds light into the complexity and evolution of the subtelomeres, structures that are critical for genome integrity.

Telomere and Genome Stability
Biology of Genomes
July 26, 2021

A press release from the ANRS on our eLife article

 

Analytical Genomics
July 19, 2021

We provided crucial insights to the molecular mechanism through which HBV infects cells. A fusion peptide in preS1 and the human protein-disulfide isomerase ERp57 are involved in HBV membrane fusion process.

Link to the article

Analytical Genomics
Article
July 14, 2021

The startup BIOMEMORY, cofounded by Stéphane Lemaire and Pierre Crozet with Erfane Arwani is the winner of the 23rd i-Lab 2021 innovation competition. The "i-Lab" objective is to detect projects for the creation of innovative technology companies and to support the best of them with financial aid and appropriate follow-up. Congratulations to Stephane, Pierre and Erfane! See the article here.

Synthetic and Systems Biology of Microalgae
Award
July 14, 2021

Gilles FISCHER has been elected Directeur of the Sorbonne University Initiative iBio. Congratulation Gilles!

Biology of Genomes
Award
July 1, 2021

Elodie Laine, from the Analytical Genomics team, is co-organizig two events addressing the new challenges in structural biology and bioinformatics, with a particular focus on Artificial Intelligence and Integrative Modeling.

— Structural Bioinformatics Mini-Symposium @JOBIM

It will take place on Thursday 8th July, in the afternoon, on air. You need to be registered to JOBIM 2021 to attend! The program can be found here: https://research.pasteur.fr/en/event/jobim-mini-symposium-integrative-structural-modeling-in-the-era-of-big-data-and-artificial-intelligence/
— New directions of AI in structural biology Workshop @CIRM

A small in-person gathering intended to mix « structuralists » and « machine learnists » and to foster new ideas and projects. There is still room, so please consider applying through: https://conferences.cirm-math.fr/2700.html.

Analytical Genomics
Event
June 28, 2021

A two-years position as Engineer in bioinformatics is open in the "Synthetic and Systems Biology of Microalgae" team.
Find here the description

Job

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