The Laboratory of Computational and Quantitative Biology (LCQB), headed by A. Carbone, is an interdisciplinary laboratory working at the interface between biology and quantitative sciences. It is built to promote a balanced interaction of theoretical and experimental approaches in biology and to foster the definition of new experimental questions, data analysis and modeling of biological phenomena. Our projects address questions on biological structures and processes through the gathering of experimental measures, the in silico generation of new biological data that remain inaccessible to experiments today (modeling of biological systems), the development of statistical methods for data analysis, and the conception of original algorithms aimed to predictions. The lab is supported by the CNRS and the University Pierre and Marie Curie (UPMC).

Upcoming Events

June 1, 2015

Ingrid Lafontaine (Biology of Genomes team) and Jean-Pierre Bouly (Diatom Genomics team), organize the symposium "Comunication between genomes"

Registration is now open

July 7-10, 2015

Angela Falciatore co-organizes the International Conference "The molecular life of Diatoms 2015", 7-10 July 2015, Seattle, USA.

Registration is now open

July 12-16, 2015

The symposium The evolution of alternative splicing  is co-organized within the framework of the 2015 meeting of the Society for Molecular Biology and Evolution by E. Laine (LCQB), H. Richard (LCQB), and J. Roux (UNIL). The event will take place in Vienna, Austria.
Registration is now open.  Abstract submission for oral presentation closes on February 8th.

December 1, 2015

Marco Cosentino Lagomarsino co-organizes the 3rd edition of Quantitative Methods in Gene Regulation. Website not yet avalaible.

News

May 10, 2015 

The LCQB-IBPS is seeking to recruit an outstanding group leader to develop interdisciplinary approaches in the following fields:
• Synthetic biology or genome engineering
• Heritability of complex traits and/or experimental evolution
• Single cell functional genomics
• Environmental genomics

March 30, 2015

The paper "Combined collapse by bridging and self-adhesion in a prototypical polymer model inspired by the bacterial nucleoid"
from the Genomic Phisics was selected for the cover page on the journal Soft Matter, 8, 2015. 

March 10, 2015

Nitric oxyde oxydases are enzymes which contributes to the resistance of pathogenic microbes to the innate immune system by detoxifying nitric oxide. "The genetic networks" team identified a new regulator of the expression of nitric oxydases in fungi and deciphered its functioning and evolution in different pathogenic and non-pathogenic yeast species. 

http://www.ncbi.nlm.nih.gov/pubmed/25732006

December 1, 2014

A. Gillet-Markowska, H. Richard, G. Fischer & I. Lafontaine just published a new tool - Ulysses - providing an accurate detection of low-frequency structural variations in large insert-size sequencing libraries. Ulysses is a valuable tool for the characterization of somatic mosaicism in human tissues and in cancer genomes.
Ulysses: accurate detection of low-frequency structural variations in large insert-size sequencing libraries
Bioinformatics 2014; doi: 10.1093/bioinformatics/btu730

November 13-14, 2014

The 4th Cross Disciplinary Genomics meeting "Up-and-Coming Advances in Genome Sciences" will be held at UPMC, in the Jussieu Campus.

There is no participation fee but registration is required.

November 10, 2014

The "Biology of Genomes" team and the "Intraspecific Variation and Genome Evolution" team from the Université de Strasbourg have published the first population genomics survey in a yeast different form a Saccharomyces species. This study reveals that consequently to a large-scale introgression event, two different mutational regimes can coexist within the same genome.

November 7, 2014

Alice Coucke, Eleonora De Leonardis and Matteo Figliuzzi (Statistical Genomics Group) and Vittore Scolari (Genomic Physics Group) co-organize the 2nd edition of the conference:
Paris Biological Physics Community Day 2014

The conference will be held at Centre Culturel Irlandais in Paris

October 8-10, 2014

The international meeting "Protein-Protein Interactions on the Genome Scale" is organized within the framework of the MAPPING project (Investissement d'Avenir en Bioinformatique) by A.Carbone.
The event will take place at UPMC, Jussieu Campus.
Registrations are open.

July 15-August 8, 2014

A.Carbone and E.Laine, from the Analytical Genomics Team, organize the ICS Summer School 2014 "Scientific Trends at the Interfaces - Bioinformatics and Scientific Visualization". Information on the school can be downloaded here.

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