Biology of Genomes

A. Gillet-Markowska, H. Richard, G. Fischer & I. Lafontaine just published a new tool - Ulysses - providing an accurate detection of low-frequency structural variations in large insert-size sequencing libraries. Ulysses is a valuable tool for the characterization of somatic mosaicism in human tissues and in cancer genomes.
Ulysses: accurate detection of low-frequency structural variations in large insert-size sequencing libraries
Bioinformatics 2014; doi: 10.1093/bioinformatics/btu730

The "Biology of Genomes" team and the "Intraspecific Variation and Genome Evolution" team from the Université de Strasbourg have published the first population genomics survey in a yeast different form a Saccharomyces species. This study reveals that consequently to a large-scale introgression event, two different mutational regimes can coexist within the same genome.

The Biology of Genomes team participated to the complete design and synthesis of the first eukaryotic synthetic chromosome. We compared replication dynamics of synthetic and native chromosome III and saw few dramatic changes in spite of several autonomously replicating sequences having been deleted.

Total Synthesis of a Functional Designer Eukaryotic Chromosome. Annaluru, Muller et al., Science (2014) DOI:10.1126/science.1249252

The Biology of Genomes and the Genomic Physics teams just published a joint work: Nicolas Agier, Orso Maria Romano, Fabrice Touzain, Marco Cosentino Lagomarsino and Gilles Fischer, The spatio-temporal program of replication in the genome of Lachancea kluyveri" Genome Biology and Evolution, in press, 2013.

An ATIP-Avenir Plus 2013-2014 was awarded to Gilles Fischer and his team Biology of Genomes