The Laboratory of Computational and Quantitative Biology (LCQB), headed by A. Carbone, is an interdisciplinary laboratory working at the interface between biology and quantitative sciences. It is built to promote a balanced interaction of theoretical and experimental approaches in biology and to foster the definition of new experimental questions, data analysis and modeling of biological phenomena. Our projects address questions on biological structures and processes through the gathering of experimental measures, the in silico generation of new biological data that remain inaccessible to experiments today (modeling of biological systems), the development of statistical methods for data analysis, and the conception of original algorithms aimed to predictions. The lab is supported by the CNRS and the University Pierre and Marie Curie (UPMC).

Upcoming Events

December 18-19, 2017

 Marco Cosentino Lagomarsino of the GenomicPhysics team organizes the conference Quantitative Methods in Gene Regulation IV ( here you may find the poster image).

News

December 1, 2014

A. Gillet-Markowska, H. Richard, G. Fischer & I. Lafontaine just published a new tool - Ulysses - providing an accurate detection of low-frequency structural variations in large insert-size sequencing libraries. Ulysses is a valuable tool for the characterization of somatic mosaicism in human tissues and in cancer genomes.
Ulysses: accurate detection of low-frequency structural variations in large insert-size sequencing libraries
Bioinformatics 2014; doi: 10.1093/bioinformatics/btu730

November 13-14, 2014

The 4th Cross Disciplinary Genomics meeting "Up-and-Coming Advances in Genome Sciences" will be held at UPMC, in the Jussieu Campus.

There is no participation fee but registration is required.

November 10, 2014

The "Biology of Genomes" team and the "Intraspecific Variation and Genome Evolution" team from the Université de Strasbourg have published the first population genomics survey in a yeast different form a Saccharomyces species. This study reveals that consequently to a large-scale introgression event, two different mutational regimes can coexist within the same genome.

November 7, 2014

Alice Coucke, Eleonora De Leonardis and Matteo Figliuzzi (Statistical Genomics Group) and Vittore Scolari (Genomic Physics Group) co-organize the 2nd edition of the conference:
Paris Biological Physics Community Day 2014

The conference will be held at Centre Culturel Irlandais in Paris

October 8-10, 2014

The international meeting "Protein-Protein Interactions on the Genome Scale" is organized within the framework of the MAPPING project (Investissement d'Avenir en Bioinformatique) by A.Carbone.
The event will take place at UPMC, Jussieu Campus.
Registrations are open.

July 15-August 8, 2014

A.Carbone and E.Laine, from the Analytical Genomics Team, organize the ICS Summer School 2014 "Scientific Trends at the Interfaces - Bioinformatics and Scientific Visualization". Information on the school can be downloaded here.

March 28, 2014

The Biology of Genomes team participated to the complete design and synthesis of the first eukaryotic synthetic chromosome. We compared replication dynamics of synthetic and native chromosome III and saw few dramatic changes in spite of several autonomously replicating sequences having been deleted.

Total Synthesis of a Functional Designer Eukaryotic Chromosome. Annaluru, Muller et al., Science (2014) DOI:10.1126/science.1249252

February 8, 2014

A World Community Grid Lecture Series webcast describing the work done by the team and its collaborators on protein-protein interactions, within the framework of the "Help Cure Muscular Dystrophy" project can be found here.

January 23-24, 2014

Hugues Richard co-organizes the 10th edition of the workshop: Statistical Methods for (Post-) Genomics Data (SMPGD). 

The Laboratory Genomics of Microorganisms will hosts the meeting at the UPMC main campus, Paris, France.

December 24, 2013

Gherardi M, Mandrà S, Bassetti B, Cosentino Lagomarsino M, "Evidence for soft bounds in Ubuntu package sizes and mammalian body masses"

Proc Natl Acad Sci USA. 2013 Dec 24;110(52):21054-8.

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