The Laboratory of Computational and Quantitative Biology (LCQB), headed by A. Carbone, is an interdisciplinary laboratory working at the interface between biology and quantitative sciences. It is built to promote a balanced interaction of theoretical and experimental approaches in biology and to foster the definition of new experimental questions, data analysis and modeling of biological phenomena. Our projects address questions on biological structures and processes through the gathering of experimental measures, the in silico generation of new biological data that remain inaccessible to experiments today (modeling of biological systems), the development of statistical methods for data analysis, and the conception of original algorithms aimed to predictions. The lab is supported by the CNRS and Sorbonne Université.

News

July 14, 2021

Gilles FISCHER has been elected Directeur of the Sorbonne University Initiative iBio. Congratulation Gilles!

July 1, 2021

Elodie Laine, from the Analytical Genomics team, is co-organizig two events addressing the new challenges in structural biology and bioinformatics, with a particular focus on Artificial Intelligence and Integrative Modeling.

 Structural Bioinformatics Mini-Symposium @JOBIM

It will take place on Thursday 8th July, in the afternoon, on air. You need to be registered to JOBIM 2021 to attend! The program can be found here: https://research.pasteur.fr/en/event/jobim-mini-symposium-integrative-structural-modeling-in-the-era-of-big-data-and-artificial-intelligence/
— New directions of AI in structural biology Workshop @CIRM

A small in-person gathering intended to mix « structuralists » and « machine learnists » and to foster new ideas and projects. There is still room, so please consider applying through: https://conferences.cirm-math.fr/2700.html.

June 28, 2021

A two-years position as Engineer in bioinformatics is open in the "Synthetic and Systems Biology of Microalgae" team.
Find here the description

May 27, 2021

A global study of 60 cities' microbes finds each has a signature microbial fingerprint. The project provides a great way to communicate about the invisible world of commensal microorganisms. Members at the LCQB, L3 and M1 Sorbonne’s students involved in our Bioinformatics courses and colleagues from other Sorbonne departments contributed to the collect of the samples for the Paris area. The article just appeared in Cell.

April 13, 2021

Juliana Bernardes of the Statistical Genomics and Biological Physics organized the MABI (Matinée sur les applications de la bio-informatique) on the 13th of April 2021.

MABI is an online event for undergraduate/graduate students interested in genomic/bioinformatic and their applications in biotechnology companies. GenoScreen, GenoSplice, iMEAN, and Pathoquest will talk about their activities and prospects in the field of bioinformatics.

To join this event, please fill this form: https://docs.google.com/forms/d/e/1FAIpQLSdspzSQi0I7pl5RSA4TxvyU8QtjK4ziiZVwDli-6BTwtklLxg/viewform

April 13, 2021

To avoid deleterious misfolding of proteins, the assembly of multiprotein complexes is tightly controlled and can either occur co-translationally in the cytoplasm or as a spatially restricted event by targetting ribosomes at particular subcellular locations. In an article recently published in Molecular Cell, Benoit Palancade's team (Institut Jacques Monod) showed that both phenomenon are at play in the biogenesis of the nucleopore, one of the largest multiprotein complex in the cells. The "genetics networks" team from LCQB contributed to this work by conducting genome-wide analyses of the interactions between nucleoporins (key nucleopore subunits) during translation 

link to the article

February 3, 2021

Our analysis of "soft disorder" makes the cover of the PLoS Computational Biology January issue.

Link to the paper
 

October 14, 2020

The first edition of Meet-EU was launched last Friday! Students enrolled in Bioinformatics Master programs from the 4EU+ alliance will join their efforts to predict chromatin organisation from Hi-C data. The LCQB is involved in the organisation of this edition, and in the training of the students!

The full opening session is available at: https://www.youtube.com/watch?v=-x5gzjqB6ms&feature=youtu.be.

July 15, 2020

The new book "Mathematical modelling of evolution. One-locus and multi-locus theory and recombination" by Igor Rouzine appeared in the Mathematical and Life Science Series of De Gruyter. Chp 1. Thought experiments based on a basic model of stochastic evolution of a single genomic site, with random mutation, directional natural selection, and random genetic drift. Chp 2. more advanced theory for a large number of linked loci. Chp 3. Genetic recombination and advantage of sexual reproduction for adaptation.
These models are directly applicable to both asexual and sexual populations, including virus populations in an animal host and a population of hosts.

Link to the book
Link to the book series

Pages