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Analytical Genomics

July 26, 2021

A press release from the ANRS on our eLife article

 

July 19, 2021

We provided crucial insights to the molecular mechanism through which HBV infects cells. A fusion peptide in preS1 and the human protein-disulfide isomerase ERp57 are involved in HBV membrane fusion process.

Link to the article

July 1, 2021

Elodie Laine, from the Analytical Genomics team, is co-organizig two events addressing the new challenges in structural biology and bioinformatics, with a particular focus on Artificial Intelligence and Integrative Modeling.

 Structural Bioinformatics Mini-Symposium @JOBIM

It will take place on Thursday 8th July, in the afternoon, on air. You need to be registered to JOBIM 2021 to attend! The program can be found here: https://research.pasteur.fr/en/event/jobim-mini-symposium-integrative-structural-modeling-in-the-era-of-big-data-and-artificial-intelligence/
— New directions of AI in structural biology Workshop @CIRM

A small in-person gathering intended to mix « structuralists » and « machine learnists » and to foster new ideas and projects. There is still room, so please consider applying through: https://conferences.cirm-math.fr/2700.html.

May 27, 2021

A global study of 60 cities' microbes finds each has a signature microbial fingerprint. The project provides a great way to communicate about the invisible world of commensal microorganisms. Members at the LCQB, L3 and M1 Sorbonne’s students involved in our Bioinformatics courses and colleagues from other Sorbonne departments contributed to the collect of the samples for the Paris area. The article just appeared in Cell.

February 3, 2021

Our analysis of "soft disorder" makes the cover of the PLoS Computational Biology January issue.

Link to the paper
 

May 12, 2020

ANRS communicates today on our new webserver COVTree, designed to predict coevolving residues in overlapping genes and to detect mirrored coevolution.

Link to the article

May 11, 2020

Interested in phylogenetic reconstruction based on synteny rather than protein sequence? PhyChro is out in MBE. This is the last piece of a huge work, CHROnicle , done in collaboration by the Analytical Genomics and the Biology of Genomes teams.

Link to the article

 

May 10, 2020

Overlapping genes are commonplace in viruses and play an important role in their function and evolution. Coevolution in OVerlapped sequences by Tree analysis (COVTree) is a web server providing the online analysis of coevolving amino-acid pairs in overlapping genes, where residues might be located inside or outside the overlapping region.

Link to the article

May 4, 2020

We propose PhyloSofS, the first automated tool to reconstruct plausible evolutionary scenarios explaining a set of observed transcripts, and to generate 3D molecular models of the protein isoforms. We apply it to the JNK family (60 transcripts, 7 trees) to identify AS events of ancient origin and relate their functional outcome with changes in the protein dynamics. We also show that PhyloSofS can help identify new potential therapeutic targets.

Link to the paper

 

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