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Biology of Genomes


Our research projects aim at understanding the biology and the evolution of eukaryotic genomes. We are combining an experimental approach on yeast species based on molecular genetics and functional genomics to an analytical exploration of genome sequences requiring bio-informatic skills and the development of new tools.

We study genome dynamics through the characterization of the structural variations of chromosomes and sequence polymorphisms at different scales, from cells to populations, and from strains and to species.

We are interested by the relationships between replication/recombination and the evolution of gene content, of gene organization along chromosomes and of protein sequences.

We also seek for the molecular mechanisms responsible for chromosomal rearrangements and for the variations of the nucleotide composition within and between genomes

Selected Publications
Yue J-X, Li J, Aigrain L, Hallin J, Persson K, Oliver K, Bergstrom A, Coupland P, Warringer J, Cosentino Lagomarsino M, Fischer G, Durbin R, Liti G.
Contrasting evolutionary genome dynamics between domesticated and wild yeasts.
Nat Genet. 49(6), pp.913-924 (2017).
Agier N, Fischer G
A Versatile Procedure to Generate Genome-Wide Spatiotemporal Program of Replication in Yeast Species.
in Yeast Functional Genomics. 1361, Springer New York. pp. 247-264 (2016)
Vakirilis N, Sarilar V, Drillon G, Fleiss A, Agier N, Meyniel J-P, Blanpain L, Carbone A, Devillers H, Dubois K, Gillet-Markowska A, Graziani S, Huu-Vang N, Poirel M, Reisser C, Schott J, Schacherer J, Lafontaine I, Llorente B, Neuvéglise C, Fischer G.
Reconstruction of ancestral chromosome architecture and gene repertoire reveals principles of genome evolution in a model yeast genus.
Genome Res. (2016).
Gillet-Markowska A, Louvel G, Fischer G.
bz-rates: A Web Tool to Estimate Mutation Rates from Fluctuation Analysis.
G3: Genes|Genomes|Genetics. (2015).
Friedrich A, Jung P, Reisser C, Fischer G, Schacherer J.
Population genomics reveals chromosome-scale heterogeneous evolution in a protoploid yeast.
Molecular Biology and Evolution. 32(1), (2015).
Gillet-Markowska A, Richard H, Fischer G, Lafontaine I.
Ulysses: accurate detection of low-frequency structural variations in large insert-size sequencing libraries.
Bioinformatics. 31(6), pp.801-8 (2015).
Louvel H, Gillet-Markowska A, Liti G, Fischer G.
A set of genetically diverged Saccharomyces cerevisiae strains with markerless deletions of multiple auxotrophic genes.
Yeast. 31(3), pp.91-101 (2014).
Drillon G, Carbone A, Fischer G.
SynChro: a fast and easy tool to reconstruct and visualize synteny blocks along eukaryotic chromosomes.
PLoS One. 9(3), pp.e92621 (2014).
Annaluru N, Muller H, Mitchell LA, Ramalingam S, Stracquadanio G, Richardson SM, Dymond JS, Kuang Z, Scheifele LZ, Cooper EM, Cai Y, Zeller K, Agmon N, Han JS, Hadjithomas M, Tullman J, Caravelli K, Cirelli K, Guo Z, London V, Yeluru A, Murugan S, Kandavelou K, Agier N, Fischer G, Yang K, J Martin A, Bilgel M, Bohutski P, Boulier KM, Capaldo BJ, Chang J, Charoen K, Choi WJin, Deng P, DiCarlo JE, Doong J, Dunn J, Feinberg JI, Fernandez C, Floria CE, Gladowski D, Hadidi P, Ishizuka I, Jabbari J, Lau CYL, Lee PA, Li S, Lin D, Linder ME, Ling J, Liu J, Liu J, London M, Ma H, Mao J, McDade JE, McMillan A, Moore AM, Oh WChan, Ouyang Y, Patel R, Paul M, Paulsen LC, Qiu J, Rhee A, Rubashkin MG, Soh IY, Sotuyo NE, Srinivas V, Suarez A, Wong A, Wong R, Xie WRose, Xu Y, Yu AT, Koszul R, Bader JS, Boeke JD, Chandrasegaran S.
Total synthesis of a functional designer eukaryotic chromosome.
Science. 344(6179), pp.55-8 (2014).
Agier N, Romano OMaria, Touzain F, Cosentino Lagomarsino M, Fischer G.
The spatiotemporal program of replication in the genome of Lachancea kluyveri.
Genome Biol Evol. 5(2), pp.370-88 (2013).
Agier N, Fischer G.
The mutational profile of the yeast genome is shaped by replication.
Mol Biol Evol. 29(3), pp.905-13 (2012).
Drillon G, Fischer G.
Comparative study on synteny between yeasts and vertebrates.
C R Biol. 334(8-9), pp.629-38 (2011).

Open Positions