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Statistical Genomics and Biological Physics

May 2, 2020

The team "Statistical Genomics and Biological Physics" has obtained financial support by the Faculty of Sciences and Engineering of Sorbonne Université, to develop sequence-data driven models of evolutionary landscapes and selective constraints acting in the Covid-19 causing virus SARS-CoV-2. The projects aims at finding signatures of selection in the rapidly increasing number of available 
genomes, and to interpret them in terms of protein structure, function and protein-protein interactions inside coronaviruses and with the host (e.g. the famous interaction of the viral spike protein with the human ACE2 receptor). 

November 15, 2019

Nonribosomal peptide synthetases (NRPSs) are microbial megaenzymes that make a wide variety of small-molecule products, including many that are clinically used as antitumors, antibiotics, or immunosuppressants. Peptide synthesis proceeds with assembly-line logic, where each station on the NRPS assembly line is a multidomain unit called a module. While the function of single modules is well studied, much less is known how they work together. Researchers from the Schmeing lab at McGill University have resolved several dimodular NRPS structures, which show coordinated interactions between modules, and large conformational changes between catalytically relevant states. Martin Weigt from the “Statstical Genomics and Biological Physics” team has performed complementary coevolutionary analyses using the direct coupling analysis (DCA), which confirm the biological relevance and evolutionary conservation of the observed inter-modular interactions. DCA analysis has also allowed to suggest mutations in a module-swapped chimeric NRPS protein, which significantly increased the activity of the protein, a result of direct relevance toward the longstanding goal of NRPS bioengineering for production of new-to-nature bioactive small molecules.

Link to article in Science

September 13, 2017

We highlight our new database Plasmobase to the community working in malaria with a new blog appeared in malariaworld.org.

June 2, 2017

Plasmobase is a unique database designed for the comparative study of 11 Plasmodium genomes. Plasmobase proposes new domain architectures as well as new domain families that have never been reported before for these genomes. It allows for an easy comparison among architectures within Plasmodium species and with other species, described in UniProt. Joint work of J.Bernardes and A.Carbone.

Server
To the article

September 15, 2016

The LCQB laboratory is in the CNRS Journal for his project MetaSUB Paris.

To the Article (Journal du CNRS)
To the Article (CNRSNews) 

July 20, 2016

Reviens Avec Tes Prélèvements et analyse les Big Data avec nous

MetaSUB Paris : Cartographier la Diversité Microbienne du Métro Parisien. An article by Marie Pinhas (UPMC) in french to explain the involvement of the lab in the MetaSUB project. 

July 11-16, 2016

Martin Weigt co-organizes the conference "Statistical physics methods in biology and computer science", a satellite of StatPhys2016, Ecole Normale Superieure, Paris, July 11-16, 2016. It will cover recent progress on the use of methods from statistical mechanics of disordered systems for high dimensional problems related to biology and computer science. Organizers: Simona Cocco, Florent Krzakala, Remi Monasson, Guilhem Semerjian, Martin Weigt, Lenka Zdeborova. 

July 8, 2016

We published a new generation domain annotation approach, demonstrating that "multi-source" domain modelling is more appropriate than "mono-source" domain modelling for capturing remote homology. We re-annotate the Plasmodium falciparum genome.

To the Software

April 17-23, 2016

Martin Weigt organizes the workshop "Coevolution in proteins and RNA, theory and experiments" in Cargèse, Corsica

March 1, 2016

A.E. Fortunato, M. Jaubert, J.P. Bouly, M. Thaler and A. Falciatore from the Diatom Functional Genomics team in collaboration with J.S. Bernardes (Statistical Genomics and Biological Physics), A. Carbone (Analytical Genomics) and other international collaborators published on The Plant Cell the paperDiatom Phytochromes Reveal the Existence of Far-Red-Light-Based Sensing in the Ocean.”  Full text paper.

Plant Cell Editor’s comment on this work.

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